Correlation of pathogenicity and gene constellation of an influenza a virus (fowl plague) I. Exchange of a single gene
Identifieur interne : 002A73 ( Main/Exploration ); précédent : 002A72; suivant : 002A74Correlation of pathogenicity and gene constellation of an influenza a virus (fowl plague) I. Exchange of a single gene
Auteurs : C. Scholtissek [Allemagne] ; R. Rott [Allemagne] ; M. Orlich [Allemagne] ; E. Harms [Allemagne] ; W. Rohde [Allemagne]Source :
- Virology [ 0042-6822 ] ; 1977.
English descriptors
- Teeft :
- Academic press, Apathogenic, Chick, Chick embryo cells, Clear correlation, Double infection, Embryo, Fowl, Fowl plague virus, Hemagglutinin, High titers, Hong kong, Influenza, Influenza viruses, Neuraminidase, Pathogenicity, Recombinant, Rott, Scholtissek, Segment composition, Single gene, Swine influenza virus, Virology, Wild type, Wild type strain, Wild type virus.
Abstract
Abstract: Recombinants of fowl plague virus (FPV) with other influenza A prototype strains of human and animal origin in which only a single gene (RNA segment) is not derived from FPV were tested for their pathogenicity in chickens. Most of these recombinants had a lowered pathogenicity, while some were completely apathogenic. The apathogenic recombinants induced high titers of antibodies against the surface components of FPV in the infected chickens which were protected against a challenge infection with wild type FPV. Loss of pathogenicity depended on the gene which was exchanged as well as on the influenza A strain of which the foreign gene was derived, but no specific gene constellation could be detected for apathogenic recombinants. There is no clear correlation between growth rate and pathogenicity, indicating that other factors such as organ tropism might also play an important role in pathogenicity of influenza viruses.
Url:
DOI: 10.1016/0042-6822(77)90059-9
Affiliations:
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Orlich</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institut für Virologie, Justus Liebig-Uniuersität, Giessen</wicri:regionArea><wicri:noRegion>Giessen</wicri:noRegion><wicri:noRegion>Giessen</wicri:noRegion></affiliation></author><author><name sortKey="Harms, E" sort="Harms, E" uniqKey="Harms E" first="E." last="Harms">E. Harms</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institut für Virologie, Justus Liebig-Uniuersität, Giessen</wicri:regionArea><wicri:noRegion>Giessen</wicri:noRegion><wicri:noRegion>Giessen</wicri:noRegion></affiliation></author><author><name sortKey="Rohde, W" sort="Rohde, W" uniqKey="Rohde W" first="W." last="Rohde">W. Rohde</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institut für Virologie, Justus Liebig-Uniuersität, Giessen</wicri:regionArea><wicri:noRegion>Giessen</wicri:noRegion><wicri:noRegion>Giessen</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Virology</title><title level="j" type="abbrev">YVIRO</title><idno type="ISSN">0042-6822</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1977">1977</date><biblScope unit="volume">81</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="74">74</biblScope><biblScope unit="page" to="80">80</biblScope></imprint><idno type="ISSN">0042-6822</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0042-6822</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Academic press</term><term>Apathogenic</term><term>Chick</term><term>Chick embryo cells</term><term>Clear correlation</term><term>Double infection</term><term>Embryo</term><term>Fowl</term><term>Fowl plague virus</term><term>Hemagglutinin</term><term>High titers</term><term>Hong kong</term><term>Influenza</term><term>Influenza viruses</term><term>Neuraminidase</term><term>Pathogenicity</term><term>Recombinant</term><term>Rott</term><term>Scholtissek</term><term>Segment composition</term><term>Single gene</term><term>Swine influenza virus</term><term>Virology</term><term>Wild type</term><term>Wild type strain</term><term>Wild type virus</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Recombinants of fowl plague virus (FPV) with other influenza A prototype strains of human and animal origin in which only a single gene (RNA segment) is not derived from FPV were tested for their pathogenicity in chickens. Most of these recombinants had a lowered pathogenicity, while some were completely apathogenic. The apathogenic recombinants induced high titers of antibodies against the surface components of FPV in the infected chickens which were protected against a challenge infection with wild type FPV. Loss of pathogenicity depended on the gene which was exchanged as well as on the influenza A strain of which the foreign gene was derived, but no specific gene constellation could be detected for apathogenic recombinants. There is no clear correlation between growth rate and pathogenicity, indicating that other factors such as organ tropism might also play an important role in pathogenicity of influenza viruses.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country></list><tree><country name="Allemagne"><noRegion><name sortKey="Scholtissek, C" sort="Scholtissek, C" uniqKey="Scholtissek C" first="C." last="Scholtissek">C. Scholtissek</name></noRegion><name sortKey="Harms, E" sort="Harms, E" uniqKey="Harms E" first="E." last="Harms">E. Harms</name><name sortKey="Orlich, M" sort="Orlich, M" uniqKey="Orlich M" first="M." last="Orlich">M. Orlich</name><name sortKey="Rohde, W" sort="Rohde, W" uniqKey="Rohde W" first="W." last="Rohde">W. Rohde</name><name sortKey="Rott, R" sort="Rott, R" uniqKey="Rott R" first="R." last="Rott">R. Rott</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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